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Experimental data convincingly demonstrate that disruption of this bidirectional interaction in AP creates a vicious circle of Ca 2+ toxicity, energy depletion, and progressive cell death ( 2+ entry remains physiologically coupled to secretion or shifts toward sustained injury signaling

In recent clinical trials in persons with obesity or overweight with associated conditions, tirzepatide decreased body weight and other cardiorenal risk factors (blood pressure, low-density lipoprotein cholesterol, glycated hemoglobin and albuminuria)

Significant ketogenesis, diminished by L-carnitine supplementation, clearly lowered oxidative stress parameters (e.g., reduction in malonic dialdehyde concentration) in patients with propionic or methylmalonic acidosis during starvation [132,133]

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